BOSTON (CBS) – Eight Massachusetts Botox providers have been sent letters from the U.S. Food and Drug Administration warning them they may have unapproved and unsafe versions of the anti-wrinkle injection.

The FDA has alerted more than 350 medical practices across the country that they may have received the unapproved Botox from foreign suppliers owned by Canada Drugs.

Without the FDA’s approval, the agency cannot vouch for the safety and effectiveness of the product or if the box has the appropriate warnings for patients.

Botox providers in Hyannis, Framingham, Newbury, Fall River, Melrose, Marblehead and Dartmouth have been contacted according to the FDA’s list.

The Massachusetts providers include two plastic surgeons, three oral surgeons, one dermatologist and one spa.

The suppliers owned and operated by Canada Drugs and known under the following names: Quality Specialty Products (QSP), A+ Health Supplies, QP Medical, Bridgewater Medical, or Clinical Care.

According to the FDA, Canada Drugs has tried to ship unapproved and counterfeit cancer drugs in the past.

The agency warns doctors about of buying drugs from foreign suppliers.