By Elizabeth Cohen, CNN


(CNN) — This year’s flu vaccine is “not a very good match” for a common strain of the flu that’s especially tough on children, according to the nation’s top infectious disease doctor.

“It’s not a very good match for B/Victoria,” said Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, referring to the strain. “It’s not an awful match, but it’s not a very good match.”

Children are particularly susceptible to influenza B/Victoria.

Fauci said even though the match for B/Victoria isn’t great, a flu shot can still save your child’s life.

That’s because the vaccine is a 58% match for B/Victoria, according to CDC data released last week. That means if your child is exposed to B/Victoria, there’s a 58% chance that their flu shot will be well matched to protect against it.

There’s a 42% chance that the vaccine won’t be well-matched for B/Victoria, so the shot won’t do a great job of keeping them from getting the flu. But it could help protect them from getting so sick that they develop life-threatening complications, Fauci said.

In addition, the shot will likely prevent infection with the other major strain of the flu that’s out there right now. The vaccine is a “a really good match” for that strain, called H1N1.

The final assessment about how effective the flu vaccine was won’t be available until the season has ended. Vaccine mismatches, as is happening this year with B/Victoria, are not unusual.

Scientists try to match the vaccine to what is making people sick, but it’s difficult. Every spring, they try to predict what strains will be out the following flu season, which starts in October. But to some extent, it’s a bit of a guessing game.

Sometimes it works better than others. For example, this year’s match to the H3N2 strain of the virus is only 34%, which Fauci called a “poor” match. But it’s not very consequential, since there’s been little H3N2 this flu season.

“Every year, there’s always some degree of mismatch. That’s why Tony’s pushing the universal vaccine,” said Dr. Arnold Monto, a professor of epidemiology at the University of Michigan School of Public Health, referring to Fauci.

Fauci is spearheading an effort to develop a universal flu vaccine that would theoretically cover every strain of the flu over multiple flu seasons.

The-CNN-Wire
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Comments
  1. DataDrivenFP says:

    There’s some serious misreporting going on- Fauci is overstating the mismatch, and CDC says it’s actually pretty close:

    “in the current 2019–20 season, influenza B/Victoria viruses are the predominant circulating influenza virus in the United States to date (2). Influenza B viruses have not been the predominant virus in the United States since the 1992–93 season (6). B/Victoria viruses did not circulate widely during the past three influenza seasons, accounting for <10% of influenza virus isolates reported during the 2016–17 to 2018–19 seasons.

    Of the multiple genetically distinct B/Victoria virus subclades, viruses with two amino acid deletions in the hemagglutinin protein, belonging to the V1A.1 subclade, and viruses with three amino acid deletions, belonging to the V1A.2 or V1A.3 subclades, cocirculated during May–September, 2019 (1).

    Although the V1A.1 and V1A.3 subclades are genetically distinct, sera from previous studies conducted among humans vaccinated with a V1A.1 virus cross-reacted well with B/Victoria viruses with a three amino acid deletion, such as the V1A.3 viruses"

    The 58% seems to be a misunderstanding of the data: the Jan 4 MMWR says 58% of circulating flu viruses are type B. The vaccine is actually a pretty good match.

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