LAWRENCE (CBS) — Two people are dead after a wrong-way driver caused a head-on, multi-car crash on Interstate 495, Mass. State Police said. The crash closed down the entire northbound side of the highway on just before noon Wednesday.

According to State Police, a Kia Sportage, driven by a 38-year-old woman from Lawrence on the southbound side of the highway crossed over the median and sideswiped a Ford F350.

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The woman’s SUV continued and struck a Honda Pilot head-on and then hit a Toyota RAV4.

State police said the wrong-way driver and the male passenger in the Honda were pronounced dead at the scene.

It is unclear why the Kia crossed the median.

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The driver of the Honda, a 55-year-old woman from Lawrence, was taken to the hospital with serious injuries. The driver and the passenger of the Toyota, a 58-year-old woman and a 27-year-old woman both from Andover, suffered non-life threatening injuries. The driver of the Ford, a 59-year-old man from Dracut, was uninjured.

The victims’ identities have not been released.

Multiple fire trucks and ambulances responded to a head-on collision on Route 495 Wednesday (WBZ-TV)

Multiple fire trucks, ambulances, and state police cruisers responded to the scene. In the meantime, traffic was diverted to I-93 at Exit 40.

The highway reopened around 3 p.m.

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State Police will continue to investigate the cause of the crash.