WORCESTER (AP) — Officials at UMass Memorial Health Care, the dominant hospital system in central Massachusetts, say they are cutting the equivalent of 350 jobs.

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President and Chief Executive John O’Brien says the cuts, first reported by the Telegram & Gazette of Worcester, are part of an effort to trim $27 million from the chain’s $2.5 billion budget because of a leveling off of demand for inpatient services and pressure from insurers.

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The cuts include the layoffs of about 130 workers, the elimination of 120 unfilled jobs, and a reduction in hours for the equivalent of 100 full-time workers.

The cuts will affect a variety of jobs from nurses to marketing staffers.

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The system, which runs hospitals in Worcester, Leominster, Fitchburg, Clinton, Marlborough and Palmer, employees about 13,700.