BOSTON (CBS) — The flu is making it extremely difficult for Red Sox manager John Farrell to fill out his lineup cards to start the season.

The Red Sox will be without first baseman Hanley Ramirez and right fielder Mookie Betts when they open a four-game set with the Tigers in Detroit, as both sluggers deal with flu symptoms.

Betts and utility man Brock Holt both missed Wednesday night’s win over the Pirates in Boston due to the flu. Holt is in the lineup on Friday, while Betts is expected to join the team on the trip. It remains unclear when last season’s MVP runner-up will be back in the Boston lineup.

In addition to Ramirez and Betts, the Red Sox are also without shortstop Xander Bogaerts and reliever Matt Barnes, who were both placed on the bereavement list on Thursday.

So who is playing on Friday? Here’s the Red Sox lineup for the series opener in Detroit:

Brock Holt, DH
Dustin Pedroia, 2B
Andrew Benintendi, LF
Mitch Moreland, 1B
Chris Young, RF
Jackie Bradley Jr., CF
Sandy Leon, C
Pablo Sandoval, 3B
Marco Hernandez, SS
— Steven Wright, SP


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