BOSTON (AP) — Boston Mayor Thomas Menino has returned to the hospital after having a negative reaction to the antibiotics he’s taking for an infection.

A Menino spokeswoman says the longest serving mayor in city history was readmitted to Brigham and Women’s Hospital on Wednesday night and it’s unclear how long he’ll stay.

The 67-year-old mayor was first hospitalized two days before Thanksgiving after developing a bacterial infection in his left elbow on a trip to Italy, where he was attending a conference. He also had a minor operation to drain fluid from his arm.

He was released Saturday. His spokeswoman says the infection is clearing up

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